Dec 9 - BMG Deparmental Seminar

Name:                  Dr. Wayne Xu

Department:      Biochemistry & Medical Genetics

Title:                     Forming and Proofing an Innovative Idea: Two Opposing Effects (Yin and Yang) in Cancer

Date:                     Wednesday, December 9

Time:                    12:00 – 13:00

Place:                    341 Klaus Wrogemann Conference Room

Oct 7 - BMG Departmental Seminar

Speaker: Laura Thompson (PhD student with Dr. Kirk McManus) 

Title:  A High-Content Screen to Identify Novel Chromosome Instability Genes

Date:  Wednesday, October 7, 2015

Time:  Noon to 13:00

Place: 341 BMSB

Feb 11 - BMG Departmental Seminar

Presenter : Veronica Lau - M.Sc. Student with Dr. Jim Davie
Date: Wednesday, February 11, 2015
Time: 11:30 – 12:00 pm
Location: 341 BMSB
Seminar Title: The Nucleosomal Response in Colorectal Cancer

Feb 4 - BMG Departmental Seminar

Presenter #1: Lexi Ciapala - M.Sc. Student
Date: Wednesday, February 4, 2015
Time: 12:15 – 12:45 pm
Location: 626 BMSB
Seminar Title: Investigating the Role of Src Family Kinase, Feline Gardner-Rasheed, Chronic Lymphocytic Leukemia
Learning Objectives:
• Describe the characteristics of Chronic Lymphocytic Leukemia
• Describe the protein Feline Gardner-Rasheed (FGR) and its functions in several cell types
• Evaluate the experiments that have been designed to determine FGR's function in CLL

******************************

Presenter #2: Miriam Derksen – M.Sc. Student
Date: Wednesday, February 4, 2015
Time: 12:45 – 1:15 pm
Seminar Title: Effects of Oxidative Stress on the Expression, Localization and Function of Cell Death Regulatory Protein BNIP3
Learning Objectives:
• Describe the structure and function of BNIP3
• Outline the characteristics of Glioblastoma multiforme (GBM)
• Explain what is known about how BNIP3 affects GBM patient outcome

Jan 28 - BMG Departmental Seminar

Presenter: Amani Moraya - M.Sc. Student with Dr. Mark Nachtigal
Date: Wednesday, January 28, 2015
Time: 12:15 – 12:45 pm
Location: Theatre E – Dentistry Building
Seminar Title: The Problem of Chemotherapy Resistance in Human Epithelial Ovarian Cancer (EOC)
Learning Objectives:
• Understand the importance of chemotherapy resistance in human epithelial ovarian cancer
• Define clinical chemotherapy resistance in epithelial ovarian cancer
• Understand the approach to testing novel drugs for re-sensitizing chemotherapy resistant epithelial ovarian cancer cells

Dec 3 - Departmental Seminar

Presenter : Yi Yan –Ph.D. Student with Dr. Etienne Leygue
Date: Wednesday, December 3, 2014
Time: 12:15 – 12:45 pm
Location: Theatre A “Mezzanine” (2nd floor BMSB, to your right and across the hall)
Seminar Title: The bi-faceted SRA/SRAP system regulates cancer cell migration/mobility.
Learning Objectives:
• SRA/SRAP: Bifaceted Genetic System
• Approach to differentiate SRA RNA or SRAP function
• Live cell mobility assay

Nov 12 - GCCRD presentation

Presenter: Dr. Ludger Klewes

Topic: GCCRD (Core Facility) capabilities and opportunities the core facility has to offer.

Date: Wednesday, November 12th

Time: 1:30-2:30pm

Location: 341 BMSB

Nov 5 - BMG Departmental Seminar

Presenter: Sanzida Jahan - Ph.D. student with Dr. Jim Davie
Date: Wednesday, November 5, 2014
Time: 12:15 – 1:15 pm
Location: Theatre A “Mezzanine”
Seminar Title: Protein arginine methyltransferases (PRMTs) and Transcriptionally Active Chromatin Domains
Learning Objectives:

1. Discuss the role of Protein arginine methyltransferase in higher order chromatin structure
2. Delineate chromatin domain and barrier element
3. Explore the mechanisms that maintain chromatin domain structure

Oct 22 - BMG departmental seminar

Presenter: Laura Thompson - Ph.D. student with Dr. Kirk McManus
Date: Wednesday, October 22, 2014
Time: 12:15 – 1:15 pm
Location: Theatre A “Mezzanine” (2nd floor BMSB, across from the elevator and on your right)
Seminar Title: A High-Content Screen to Identify Novel Chromosome Instability Genes

Learning Objectives:
· Define chromosome instability (CIN) and discuss the importance of CIN gene identification
· Describe the assays developed in this study
· Explain how CIN assays are utilized for high-content screening and why gene validation is required

Sept 24 - Departmental Seminar

Presenter: Brent Guppy, PhD student with Dr. Kirk McManus
Date: Wednesday, September 24, 2014
Time: 12:15 – 1:15 pm
Location: Theatre A 'Mezzanine' (2nd floor BMSB, across from the elevator and on your right)
Seminar Title: Mitotic Increases in Di-methylated Lysine 79 of Histone H3 are Required for Genome Stability in Human Cells and Occur Independently of Mono-Ubiquitinated Histone H2B

August 15th - MICB/BMG Annual Barbeque

August 15
12:00 - 4:00
2015 Main Street, Kildonan Park
This is a potluck. Please sign up at the front office to bring food.
Spouses and kids are welcome to join.
Remember to bring a football or frisbee, suntan lotion, chair and mosquito repellent.

April 2 - PhD Thesis Defense for Sara Beiggi

Notice of Final PhD Oral Examination for Sara Beiggi
Department of Biochemistry & Medical Genetics
“Epidemiological Study of Chronic Lymphocytic Leukemia (CLL) in the Province of Manitoba, Canada”
DATE: WEDNESDAY, APRIL 2, 2014
TIME: 10:00 A.M.
PLACE: 341 BASIC MEDICAL SCIENCES BLDG.

March 19 - BMG Departmental Seminar

Presenter: Dr. Versha Banerji, Department of Internal Medicine & Biochemistry and Medical Genetics
Date: Wednesday, March 19, 2014
Time: 12:15 – 1:15 pm
Location: Theatre A “Mezzanine”
Seminar Title: "Inhibiting Nicotinamide phosphoribosyl transferase (NAMPT) to kill Chronic Lymphocytic Leukemia cells"

February 26 - BMG Departmental Seminar

Berardino Petrelli, M.Sc. Student with Dr. Geoff Hicks
Time: 12:45 – 1:15 pm
Location: Theatre A “Mezzanine”
Seminar Title: A FASD Mouse Model: Biochemically Mimicking Alcohol Exposure using Gsc promoter driven Cyp26A1 cDNA
Learning Objectives:
· Describe Fetal Alcohol Spectrum Disorder and the FASD continuum.
· Describe the clinical features of FAS in humans and explain the resultant phenotypic effects obtained in murine models of FAS.
· Explain the rationale for the molecular strategy and targeting of the CYP26A1:eGFP cassette to the Goosecoid (Gsc) locus and describe cassette validation techniques in vitro and in vivo.

Feb 12 - BMG Departmental Seminar

Presentation: Laura Thompson, M.Sc. Student with Dr. Kirk McManus
Date: Wednesday, February 12, 2014
Time: 12:45 – 1:15 pm
Location: Theatre A “Mezzanine”
Seminar Title: Developing a High-Content Screen to Identify Human Chromosome Instability Genes

Learning Objectives:
· Define chromosome instability (CIN) and discuss the importance of CIN gene identification
· Describe the complementary assays that are capable of detecting CIN
· Explain how CIN assays can be utilized in a high content screen of candidate genes

BIochemistry & Medical Genetics Department Seminar

Presenter: Aleksander Ilic, M.Sc. Student with Dr. Jim Davie
Date: Wednesday, February 5, 2014
Time: 12:45 – 1:15 pm
Location: Theatre A “Mezzanine”
Seminar Title: Role of UCHL1 in regulating gene expression in prostate cancer cells
Learning Objectives:
· Discuss the primary role of UCHL1 as a deubiquitinating enzyme
· Describe the UCHL1 interaction with genomic DNA and its possible role in regulating gene expression in prostate cancer
· Explain how ChIP and ChIP-seq can be utilized to map the genomic location of protein binding sites

Jan 9 - Sanzida Jahan

BMG Departmental Seminar…
Presenter: Sanzida Jahan, PhD student with Dr. Jim Davie
Title: Characterization of transcriptionally active novel histone H5 chromosomal domain using avian erythrocyte cells
Date: Wednesday, January 8, 2014
Location: Theatre A “Mezzanine”
Time: 12:15 – 1:15 pm
Learning objectives:
1. To understand the higher order chromatin structure separated by chromatin boundaries.
2. To identify signatures to characterize chromatin boundaries.
3. To characterize the mechanism of maintaining open chromatin domain.

November 27 - Brent Guppy

Presenter: Brent Guppy, PhD student with Dr. Kirk McManus
Title: Characterizing the Spatial and Temporal Dynamics of RNF20 in Colorectal Cancer
Date: Wednesday, November 27, 2013
Location: Theatre A “Mezzanine”
Time: 12:15 – 1:15 pm
Learning objectives:
- Define the differences between histone mono-ubiquitylation and protein poly-ubiquitylation
- Discuss how aberrant histone H2B ubiquitylation may lead to tumorigenesis
- Describe the trans-histone pathway

Nov 6 - BMG Departmental Seminar

Presenter: Yueqin Zhou, PhD student with Dr. Geoff Hicks
Title: ALS-Associated FUS Mutations Result in Compromised FUS Alternative Splicing and Autoregulation
Date: Wednesday, November 6, 2013
Location: Room 626 BMSB
Time: 12:15 – 1:15 pm
Learning objectives:
1. Understand the importance of studying FUS regulated RNA processing and its association with ALS.
2. Describe the autoregulation of FUS by alternative splicing.
3. Discuss the potential association between the compromise of FUS autoregulation and the pathogenesis of ALS with FUS mutation, and its therapeutic implication.

October 9 - BMG Departmental Seminar

Presenter: Alexandra Kuzyk, MD/PhD student with Dr. Sabine Mai
Title: A study of nuclear disorganization in cancer cells.
Date: Wednesday, October 9, 2013
Location: Theatre A “Mezzanine” 12:15 – 1:15 pm
Learning objectives:
· List two aspects of nuclear architecture.
· Describe the relationship between nuclear localization and transcription.
· Explain the 11E2 and 17q25 synteny region and their impact in mouse plasmacytoma and human neuroblastoma